Emergence of Increased Resistance to Quinupristin/ Dalfopristin During Therapy for Enterococcus faecium Bacteremia
نویسندگان
چکیده
منابع مشابه
Treatment of vancomycin-resistant Enterococcus faecium infections with quinupristin/dalfopristin.
Clinicians caring for patients with vancomycin-resistant Enterococcus faecium (VREF) infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin (Synercid) is active in vitro against VREF, with a MIC(90) of 1.0 microg/mL. We investigated the clinical efficacy and safety of this agent in a multicenter, prospective, noncomparative, emergency-use study of 396 patien...
متن کاملHigh rate of resistance to quinupristin-dalfopristin in Enterococcus faecium clinical isolates from Korea.
We tested the in vitro susceptibilities of 603 enterococcal isolates from eight tertiary-care hospitals in Korea. The quinupristin-dalfopristin resistance rate in Enterococcus faecium was very high (25 isolates, 10.0%). It was suggested that both clonal spread and the sporadic emergence of quinupristin-dalfopristin-resistant isolates may explain the high prevalence of quinupristin-dalfopristin ...
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Daptomycin is a cyclic lipopeptide antibiotic that has been available in the United States since September 2003. We report a clinical and bacteriological failure of daptomycin therapy for enterococcal bacteremia. Briefly, a 22-year-old man with Hodgkin’s lymphoma, subsequent acute myelogenous leukemia, and nonseminomatous testicular carcinoma developed neutropenic fever during chemotherapy in 2...
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Quinupristin-dalfopristin is a streptogramin combination active against multiply resistant Enterococcus faecium. Among 45 E. faecium isolated from patients in various French hospitals, only two strains were intermediate (MIC = 2 microgram/ml) and one, E. faecium HM1032, was resistant (MIC = 16 microgram/ml) to quinupristin-dalfopristin, according to British Society for Antimicrobial Chemotherap...
متن کاملRapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection.
We report the emergence of linezolid resistance (MICs of 16 to 32 mg/liter) in clonally related vancomycin-susceptible and -resistant Enterococcus faecium isolates from an intensive care unit patient after 12 days of linezolid therapy. Only linezolid-susceptible isolates of the same clone were detected at 28 days after termination of linezolid therapy.
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 1997
ISSN: 1058-4838,1537-6591
DOI: 10.1093/clinids/24.1.90